WebNov 9, 2012 · Rifabutin reduces serum concentrations of antiretroviral agents, but less so than rifampin. Rifapentine is also an inducer of drug metabolism. Methods: A literature search of English language ... WebFor latent tuberculosis it may be used by itself when the exposure was with drug-resistant TB. [1] Common side effects include abdominal pain, nausea, rash, headache, and low blood neutrophil levels. [1] Other side effects include muscles pains and uveitis.

Mycobutin (rifabutin) dose, indications, adverse effects, interactions …

WebFinally, if a patient whose rifabutin dose was decreased to avoid drug interactions related to co-treatment with antiretroviral therapy subsequently stops taking the interacting … potentiell kurativ

Drug Interactions between Integrase Inhibitors and Other Drugs

WebDrug Interactions Effect of Rifabutin on the Pharmacokinetics of Other Drugs Rifabutin induces CYP3A enzymes and therefore may reduce the plasma concentrations of drugs metabolized by those enzymes. This effect may reduce the efficacy of standard doses of such drugs, which include itraconazole, clarithromycin, and saquinavir. WebIn healthy volunteers, a dose of 150 mg every other day of rifabutin given together with standard dose boosted fosamprenavir resulted in an increase in amprenavir AUC and Cmax by 35% and no change in Cmin. Limited clinical data among patients with HIV. Monitor closely for uveitis, hepatotoxicity, and neutropenia. WebThere is the potential for significant drug interactions and overlapping toxicities in patients receiving medications for treatment or prevention of opportunistic infections (OIs). These patients often are receiving other medications, including antiretrovirals that interfere with metabolism or elimination of OI medications. potentiel synonymes