Phosphotyrosine binding domain

In molecular biology, Phosphotyrosine-binding domains are protein domains which bind to phosphotyrosine. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to … See more APBA1; APBA2; APBA3; APPL1; EPS8; EPS8L1; EPS8L2; EPS8L3; TENC1; TNS; TNS1; TNS3; TNS4; DOK1; DOK2; DOK3; DOK4; DOK5; DOK6; DOK7; FRS2; FRS3; IRS1; IRS2; IRS4; NOS1AP; TLN1; TLN2 See more • SH2 domains also bind phosphorylated tyrosines See more • Eukaryotic Linear Motif resource motif class LIG_PTB_Phospho_1 See more WebDec 7, 1995 · The PTB domain is structurally similar to pleckstrin homology domains (a β-sandwich capped by an α-helix) and binds to acidic phospholipids, suggesting a possible …

The Phosphotyrosine Interaction Domains of X11 and FE65 Bind …

WebApr 27, 2016 · National Center for Biotechnology Information WebMay 13, 2024 · Figure 1. Lipid-binding abilities of some SH2 domains may contribute to spatio-temporal coordination of tyrosine kinase signaling hub dynamics. Alternative … the pyramid 2014 stream https://theosshield.com

Phospho-dependent Protein Interaction Domains - Cell …

WebOct 1, 1999 · Phosphotyrosine binding (PTB) domains have been identified in a large number of proteins. In proteins like Shc and IRS-1, the PTB domain binds in a phosphotyrosine … WebWe demonstrate that the phosphotyrosine binding domain of Shc is necessary and sufficient for its association with tyrosine-phosphorylated SHIP. Through site-directed mutagenesis, we have identified two tyrosines on SHIP, Tyr-917, and Tyr-1020, as the principal contact sites for the Shc- phosphotyrosine binding domain. WebThe Phosphotyrosine Binding (PTB) domain is one of the recently described domains involved in protein-protein interactions. the pyramid 2014 teaser

Phospho-dependent Protein Interaction Domains - Cell Signaling …

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Phosphotyrosine binding domain

The Phosphotyrosine Interaction Domains of X11 and FE65 Bind …

WebMar 1, 2002 · Phosphotyrosine-binding (PTB) domains — also called phosphotyrosine-interacting domains ( PIDs) — were first identified in the SH2-domain-containing adaptor … WebMar 13, 2008 · Surprisingly, despite the absence of a known phosphotyrosine-binding domain, pyruvate kinase exhibited a ≥15:1 SILAC heavy:light ratio, identifying it as a candidate novel...

Phosphotyrosine binding domain

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WebMar 5, 2024 · Conserved Domains (3) summary cd07631 Location: 20 → 234 BAR_APPL1; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 1 cd13158 Location: 490 → 625 WebJun 11, 2014 · Hakai acts through its phosphotyrosine-binding (HYB) domain, which bears a dimeric fold that recognizes the phosphotyrosine motifs of E-cadherin, cortactin, DOK1, …

WebApr 10, 1998 · Numb is a phosphotyrosine-binding (PTB) domain-containing protein implicated in the control of cell fate decisions during development. A modified two-hybrid screen in yeast was used to identify ... WebAug 17, 2024 · Bound to the intracellular juxtamembrane region of each FGFR chain is the phosphotyrosine-binding (PTB) domain of FGF receptor substrate 2α (FRS2α).

WebFeb 26, 2003 · These motifs are part of a canonical recognition sequence for phosphotyrosine-binding (PTB) domains, protein modules that are present in a wide … WebFeb 26, 2003 · These motifs are part of a canonical recognition sequence for phosphotyrosine-binding (PTB) domains, protein modules that are present in a wide variety of signaling and cytoskeletal proteins. Indeed, talin and ICAP1-α bind to integrin β tails by means of a PTB domain–NPXY ligand interaction. To assess the generality of this …

WebOct 6, 2006 · The RET receptor tyrosine kinase is important for several different biological functions during development. The recruitment at the phosphorylated Tyr1062 site in RET of a number of different …

WebPhosphotyrosine-Binding Domain. The case for PTB domain adaptors regulating LDL receptor internalization was closed with the identification of the gene responsible for … the pyramidal geometry is associated withWebPhosphorylation may be viewed as a device to control the assembly of protein complexes, and thereby to regulate the dynamic behavior of the cell. Phospho-dependent interaction … the pyramid anubis superWebNumb is a membrane-associated, phosphotyrosine binding (PTB) domain-containing protein that functions as an intrinsic determinant of cell fate during Drosophila development. We … the pyramid and the sphinxWebApr 22, 2005 · Here we show that the C2 domain of PKCδ is a phosphotyrosine binding domain. We determine its specificity by peptide library screens, its affinity by isothermal titration calorimetry, and the structural basis for phosphotyrosine binding by X-ray diffraction of its crystal structure. signing bonus tax calculatorWebSeveral other PI domains have been identified that may also have binding specificity for the NPXY motif. The terminology used at present to define these domains is unclear. The … signing bonus tax returnsWebNov 17, 1995 · This leads to the incorporation of MA molecules into virus cores, and subsequently into uncoated viral nucleoprotein complexes. A direct interaction between … the pyramidal tractWebMar 29, 2024 · The phosphotyrosine interaction (PI) domains (also known as the PTB, or phosphotyrosine binding, domains) of Shc and IRS-1 are recently described domains that … the pyramid and mortuary complex of djoser