In molecular biology, Phosphotyrosine-binding domains are protein domains which bind to phosphotyrosine. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to … See more APBA1; APBA2; APBA3; APPL1; EPS8; EPS8L1; EPS8L2; EPS8L3; TENC1; TNS; TNS1; TNS3; TNS4; DOK1; DOK2; DOK3; DOK4; DOK5; DOK6; DOK7; FRS2; FRS3; IRS1; IRS2; IRS4; NOS1AP; TLN1; TLN2 See more • SH2 domains also bind phosphorylated tyrosines See more • Eukaryotic Linear Motif resource motif class LIG_PTB_Phospho_1 See more WebDec 7, 1995 · The PTB domain is structurally similar to pleckstrin homology domains (a β-sandwich capped by an α-helix) and binds to acidic phospholipids, suggesting a possible …
The Phosphotyrosine Interaction Domains of X11 and FE65 Bind …
WebApr 27, 2016 · National Center for Biotechnology Information WebMay 13, 2024 · Figure 1. Lipid-binding abilities of some SH2 domains may contribute to spatio-temporal coordination of tyrosine kinase signaling hub dynamics. Alternative … the pyramid 2014 stream
Phospho-dependent Protein Interaction Domains - Cell …
WebOct 1, 1999 · Phosphotyrosine binding (PTB) domains have been identified in a large number of proteins. In proteins like Shc and IRS-1, the PTB domain binds in a phosphotyrosine … WebWe demonstrate that the phosphotyrosine binding domain of Shc is necessary and sufficient for its association with tyrosine-phosphorylated SHIP. Through site-directed mutagenesis, we have identified two tyrosines on SHIP, Tyr-917, and Tyr-1020, as the principal contact sites for the Shc- phosphotyrosine binding domain. WebThe Phosphotyrosine Binding (PTB) domain is one of the recently described domains involved in protein-protein interactions. the pyramid 2014 teaser