Phospho-eif2α ser51 d9g8
WebOur data also show that the protein levels of ATF4, a down-stream factor up-regulated by eIF2α phosphorylation, significantly increase at 3 h after 50 mJ cm −2 only after using the UVB lamp (Fig. 3C, Lines 2 versus 1) and at 3 h after 200 mJ cm −2 when using the UVB/UVA lamp with and without the filter (Fig. 3C, Lines 6, 7 versus 1). WebMay 3, 2024 · Stress-responsive kinases phosphorylate eIF2α at conserved Ser51, transforming eIF2 from substrate into a competitive GEF inhibitor. ... yet eIF2Bα deletion impairs phospho-inhibition of eIF2B, consistent with the subunit’s role in binding eIF2α-P. Point mutations with identical phenotypes cluster at the interface between eIF2Bα and ...
Phospho-eif2α ser51 d9g8
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Web产品名称： eIF 2 α（总）和eIF 2 α（磷酸化Ser 51）TR-FRET检测试剂盒 - 【干冰】eIF2α (Total) and eIF2α (Phospho-Ser51) TR-FRET Assay Kit. 产品货号：500205-480. 产品规格：480wells. 背景资料：该eIF 2 α（总）和eIF 2 α（磷酸化Ser 51）TR-FRET检测试剂盒,【干冰】eIF2α (Total) and eIF2α ... Webtarget protein. Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb detects endogenous eIF2α only when phosphorylated at Ser51. The antibody does not recognize elF2α phosphorylated at other sites. Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb detects endogenous levels of p46 and p54 SAPK/JNK only when phosphorylated at Thr183 and …
Web(3398) Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb Supplier Cell Signaling Technology. Host Rabbit Type Primary Clonality Recombinant (D9G8C8D5) Recombinant Yes Conjugate Unconjugated Target Eukaryotic translation initiation factor 2 subunit 1 (Human) UniProt P05198 - IF2A_HUMAN. Gene WebSep 16, 2016 · The integrated stress response (ISR) is a cytoprotective pathway initiated upon phosphorylation of the eukaryotic translation initiation factor 2 (eIF2α) residue designated serine-51, which is...
WebSep 3, 2024 · Product-Name : Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb Size : 40 ul Price- (USD) : 135 USD Species-x-Reactivity : H, M, R, Mk, Dm Applications : Immunohistochemistry (Paraffin) Product-Category : Translational Control Shipping-Temp : AMBIENT Storage-Temp : -20°C Product-Type : Monoclonal Antibody MW : 38 Host : … WebStructural information on eIF2α reveals that Ser51 is located within a flexible loop, referred to as the Ser51 loop. Recently, we have shown that conformational change of the Ser51 …
WebNov 19, 2024 · The phosphorylation of eIF2α is controlled by four protein kinases, general-control non-derepressible-2 kinase (GCN2), double-stranded RNA-activated protein kinase (PKR), haeme-regulated inhibitor kinase (HRI), and PKR-like endoplasmic reticulum kinase (PERK) ( Ohno, 2014 ).
WebThe phosphorylation of eIF2α at Ser51 is well known to prevent a step in the initiation of translation and thereby block global protein synthesis [45,46]. eIF2α was phosphorylated in response to various cellular stresses [53,54]. We found that isopanduratin A up-regulated the level of phospho-eIF2α (Ser 51) within 1 h. raymond humm vacWebJan 1, 2024 · Primary monoclonal antibodies (clone name; catalog number) used were phospho-eIF2α Ser51 (D9G8; 3398), eIF2α (D7D3; 5324), phospho-p70 S6 kinase Thr389 (1A5; 9206), p70 S6 kinase (49D7; 2708), and α-tubulin (11H10; 2125) were obtained from Cell Signaling Technologies (Danvers, MA). simplicity\\u0027s qtWebApr 8, 2024 · The data indicate that the phospho-JNK, phospho-eiF2α, ATF4, and CHOP levels are upregulated as early as 3 h after treatment with NB extract. A slight induction in cell death, as shown by the increase in cleaved PARP, was shown at 6 h after treatment with NB extract, which became more significant after 24 h. simplicity\\u0027s qsWebNov 28, 2016 · product name : Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb catalog : 3398S quantity : 100 ul price : 301 USD clonality : monoclonal host : rabbit antigen … simplicity\u0027s qqWebAug 4, 2024 · Cell Signaling Technology's Phospho-eIF2alpha (Ser51) (D9G8) XP ® Rabbit mAb is a Rabbit monoclonal antibody. The Phospho-eIF2alpha (Ser51) (D9G8) XP ® … raymond hunter statsWebColorectal cancer (CRC) is the most common intestinal malignancy, and nearly 70% of patients with this cancer develop metastatic disease. In the present study, we synthesized … raymond huntingtonWebThe inhibition of Hsp90 prolonged ERS through the degradation of IRE1α and the dephosphorylation of eIF2α. • The suppression of autophagy reduced the expression of GRP78 and phospho-eIF2α to aggravate ERS. • Hsp90-mediated UPR and mTOR-dependent autophagy jointly promoted ERS-induced apoptosis in As 3+ /Se 4+ combination-treated … raymond humphrey englewood fl