WebIn bone marrow (BM), hematopoietic elements are mingled with adipocytes (BM-A), which are the most abundant stromal component in the niche. BM-A progressively increase … WebLeptin is an adipokine secreted by adipocytes, which is part of a negative feedback loop that modulates fat tissue by regulating appetite and energy expenditure. Inactivation of the leptin signaling in the central nervous system induces hyperphagia, leading to rapid and homogeneous weight gain ( Fig. 1 A ).
Obesity alters the long-term fitness of the hematopoietic stem …
The concept of targeting the interaction of leukemia cells with their specific niche in the BM has emerged only recently [38, 75] and adipocytes should definitively be added to the list of potential target structures. Adipocytes are highly active secretory cells and release a large variety of factors to the local … Meer weergeven When talking about AT, we usually refer to the two classical types, i.e., white adipose tissue (WAT) and brown adipose tissue (BAT) (Fig. 1). WAT covers the human body in a … Meer weergeven There is accumulating evidence that MAT also influences survival and proliferation of leukemic blasts. Decline of normal hematopoiesis during leukemia progression is a well-known phenomenon, but has only … Meer weergeven The bone cavity formed by osteoblasts harbors the BM and is home to hematopoiesis (Fig. 2a) maintained by hematopoietic … Meer weergeven We are only beginning to understand the role of MAT in normal hematopoiesis. In a landmark paper, Naveiras et al. identified MAT as negative regulator of hematopoiesis … Meer weergeven Web13 mrt. 2015 · The roles of cellular ROS in adipogenesis were investigated in vivo through an adipocyte hyperplasia marrow model under hematopoietic stress induced by arabinosylcytosine (Ara-C) and in vitro via adipocyte differentiation of human MSCs. ROS levels were detected using the CM-H 2 DCFDA probe and Mito-SOX dye. halo flashlight problem
Stem cells and chronic wound healing: state of the art CWCMR
WebHematopoietic cytokines are large family of extracellular ligands that stimulate hematopoietic cells to differentiate into eight principle types of blood cells. Numerous cytokines are involved in the regulation of hematopoiesis within a complex network of positive and negative regulators. Some cytokines have very narrow lineage specificities … Web1 jan. 2012 · Hematopoiesis is an energy-dependent process that depends on and is regulated by the adipose reserves of the body. Adipose tissue is a source of cytokines … WebCurrently, SSc is recommended as the ‘standard indication’ for autologous hematopoietic stem cell transplantation by the European Society for Blood and Marrow Transplantation. ... adipose tissue grafting Published in Cells ISSN 2073-4409 (Online) Publisher MDPI AG Country of publisher Switzerland LCC subjects Science ... halo flats london