Thalidomide, sold under the brand names Contergan and Thalomid among others, is an oral medication used to treat a number of cancers (including multiple myeloma), graft-versus-host disease, and a number of skin conditions including complications of leprosy. While thalidomide has been used in a number of HIV … See more Thalidomide is used as a first-line treatment for multiple myeloma in combination with dexamethasone or with melphalan and prednisone to treat acute episodes of erythema nodosum leprosum, as well as for … See more Thalidomide should not be used by men or women who are trying to father or conceive a child, those who cannot or will not follow the risk management program to prevent … See more The precise mechanism of action for thalidomide is not known, although efforts to identify thalidomide's teratogenic action generated 2,000 research papers and the proposal of 15 or 16 plausible mechanisms by 2000. As of 2015 , the main theories were … See more In 1952, thalidomide was synthesised by Chemical Industry Basel (CIBA), but was found "to have no effect on animals" and was discarded on that basis. In 1957, it was acquired by Chemie Grünenthal in Germany. The German company had been established … See more Thalidomide causes birth defects. The U.S. Food and Drug Administration (FDA) and other regulatory agencies have approved marketing of the drug only with an auditable risk evaluation and mitigation strategy that ensures that people using the drug are aware of … See more Thalidomide is racemic; while S-thalidomide is the bioactive form of the molecule, the individual enantiomers can racemize to each other due to the acidic hydrogen at the See more Birth defect crisis In the late 1950s and early 1960s, more than 10,000 children in 46 countries were born with deformities, such as phocomelia, as a consequence of thalidomide use. The severity and location of the deformities depended on how … See more WebThalidomide is a drug that was marketed as a sedative and treatment for morning sickness in pregnant women in the late 50s and early 60s. This drug subsequently caused babies to be born with a range of disabilities. The drug was first developed by Chemie Grunenthal in Germany in 1954 and introduced into the UK in 1958, primarily under the brand ...
Thalidomide: history, withdrawal, renaissance, and safety concerns
WebThalidomide is a teratogenic drug, meaning that when taken while pregnant, it can have terrible impacts on fetal development and cause irreversible damages. Phocomelia, a limb atrophy, is the most common malformation linked to thalidomide, but all phocomelia cases aren’t caused by thalidomide. However, due to the notoriety of the thalidomide ... WebFeb 27, 2024 · Thalidomide was the first example of a drug that passed legal specifications and regulations without full evaluation of its safety for use in pregnant and breastfeeding mothers. After 1961, drug ... honeybee quartz
Enantiomer - Wikipedia
WebThalidomide is also sometimes used to treat certain skin conditions involving swelling and irritation. It is also used to treat certain complications of human immunodeficiency virus … WebPerhaps the most dramatic example of the importance of enantiomers can be found in the case of thalidomide. Thalidomide was a drug commonly prescribed during the 1950's and 1960's in order to alleviate nausea and other symptoms of morning sickness. In fact, only one enantiomer of thalidomide had any therapeutic effect in this regard. WebDec 2, 2024 · The thalidomide tragedy was responsible for the creation of the UK’s Committee on the Safety of Drugs and the Medicines Act of 1968. Those opposed to the use of animals in medical research claim that thalidomide is an example of a medicine that was ‘tested as safe in animals’ but then went on to harm humans. honeybee purchased by blue origin