Ctr1 inhibitor

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August undefined, 2024

WebMay 8, 2015 · CTR1 is a negative regulator of the ethylene pathway, loss-of-function mutations in CTR1 resulting in constitutive ethylene responses, with phosphorylation of … WebJan 1, 2024 · Ctr1 modulates AAV-induced α-syn pathology in the nigrostriatal system. These in vitro findings suggest that α-syn pathology can be regulated by Ctr1. Given that …

The copper transporter Ctr1 contributes to cisplatin uptake by

WebNov 22, 2011 · The robust inhibition of ethylene responses in eto1, ctr1, and ACC-supplied wild-type seedlings suggested that Kyn modulates the activity of the ethylene signaling … WebSep 9, 2013 · CTR1, a high affinity Cu transporter, and CTR2, a low affinity Cu transporter belong to the family of copper transporters found in humans. CTR1 is a 32 kDa, membrane protein consisting of … list of companies owned by carlyle group

(PDF) Exosome Mediated Cytosolic Cisplatin Delivery Through …

WebOct 15, 2010 · The Ctr1 protein is a high-affinity Cu+ importer that is structurally and functionally conserved in yeast, plants, fruit flies, and humans and that, in all of these … WebJul 14, 2010 · The studies described in this report suggest that cisplatin-induced ototoxicity and cochlear uptake can be modulated by administration of a CTR1 inhibitor, copper … WebMay 3, 2024 · The anti-cancer effect of cisplatin was enhanced when delivered by exosome in vitro and in vivo . Mechanistic studies shown that exosomes deliver cisplatin mostly via clathrin-independent... images schools out for summer

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Role of the copper transporter, CTR1, in platinum-induced …

WebDec 12, 2024 · Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial signaling pathways and inhibition of this specific pathway may provide a strategy to minimize cisplatin-induced nephrotoxicity. 269 PDF View 1 excerpt, references background WebC1 esterase inhibitor (C1INH) is a plasma protein that prevents complement activation, inhibits proteases in the coagulation system such as factors XIa, XIIa and kallikrein, … images school bathroomWebJan 23, 2024 · Unexpectedly, the nuclear-localized CTR1 enhances ethylene responses through a mechanism that does not require its kinase activity. This inhibits the fast recovery of seedling growth back to... list of companies on the ftse 100

"WebA CTR1 substrate, copper sulfate, decreased the uptake and cytotoxicity of cisplatin in HEI-OC1, a cell line that expresses many molecular markers reminiscent of OHCs. Small … " - Ctr1 inhibitor

Ctr1 inhibitor

High affinity copper uptake protein 1 - Wikipedia

WebNov 6, 2012 · CTR1 consists of a unique N-terminal regulatory domain and a C-terminal serine/threonine kinase domain ( Fig. 1 A ). Because CTR1 is most similar in sequence … WebDec 12, 2024 · Studies of cisplatin-induced ototoxicity and cochlear uptake show that it can be modulated by administration of a CTR1 inhibitor, copper sulfate. In mice, intratympanic administration of copper sulfate given before intraperitoneal cisplatin dosing prevented subsequent hearing loss.

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WebCopper transporter 1 (CTR1) represents an important determinant of cisplatin resistance. A series of 35 semi-substituted steroids were recently investigated on cisplatin-resistant … WebNational Center for Biotechnology Information

WebOct 1, 2013 · The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. N. Pabla, R. Murphy, Kebin Liu, Z. Dong Biology, Chemistry American journal of physiology. Renal physiology 2009 TLDR WebThere is no significant difference between the two groups with or without CTR1 inhibitor, while cisplatin was inhibited by CTR1 inhibitor (Supplementary Figure S3), suggesting the cisplatin...

WebThe copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. The usefulness and efficacy of cisplatin, a chemotherapeutic … WebJan 23, 2024 · CTR1 inhibition results in a mild reduction in available copper, and ATP7A knockdown results in copper accumulation in the cells (Table 1). Disruption …

WebCopper transporter 1 (CTR1) is the major influx transporter of cisplatin. This study found a negative regulatory relationship between p53 and CTR1. Under cisplatin treatment, p53 …

Web潘振华刘红雨陈军. 据世界卫生组织发布的2024年GLOBOCAN数据显示，肺癌是全球发病率第二、致死率第一的肿瘤，其中非小细胞肺癌（non-small cell lung cancer, NSCLC）占85%，小细胞肺癌（small cell lung cancer, SCLC）占15%。 images school wet splashWebJul 14, 2010 · Other studies showed that using a CTR1 inhibitor copper sulfate to pretreat HEI-OC1 cells also effectively reduced the apoptosis caused by cisplatin, providing another hope for treating CIO [70 ... images school fuel grocery bagWebJul 12, 2024 · PDF Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as... Find, read and cite all the research you need on ... images school classWebDec 9, 2024 · Effect of sorafenib, an inhibitor of RAF kinase, on the number of living and dying cells during Kin-PCD and ETH as well as the activities of RAF-like and MEK2 enzymes To estimate the number of... images schoolsWebIntratympanic administration of copper sulfate, a CTR1 inhibitor, or knockdown of CTR1 with small inter- fering RNA can decrease the uptake and cytotoxicity of cisplatin and prevent hearing loss caused by cisplatin, both in vitro and in vivo [31]. images school nurseWebFeb 17, 2024 · We identify that CTR1 undergoes AMPK-mediated phosphorylation, which enhances CTR1 stabilisation and membrane translocation by affecting Nedd4l interaction, resulting in increased oncogenic roles ... images school photography in watertown ctWebNov 9, 2015 · Cisplatin-induced ototoxicity and cochlear uptake can be modulated by administration of a CTR1 inhibitor, copper sulfate, and the possibility of local administration of CTR1 inhibitors during cisplatin therapy as a … list of companies referred to nclt by rbi