Circeif4g3
WebJul 2, 2024 · CircEIF4G3 expression was downregulated in patients with GC and predicted poor prognosis. CircEIF4G3 destabilized δ-catenin by forming circEIF4G3/δ …
Circeif4g3
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WebJul 2, 2024 · Europe PMC is an archive of life sciences journal literature. WebAug 10, 2024 · The formation of a unique back-splice junction (BSJ) differentiates the circRNAs from their linear counterpart. CircRNAs are highly expressed in the central nervous system where many of them are regulated during development 1 – 3, inflammation 4, and also found to function as biomarkers in cancer 5 – 7.
Webcells Article SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion Vanessa M. Conn 1,2, Marta Gabryelska 1,2, Shashikanth Marri 1,2, Brett W. Stringer 1,2,3, Rebecca J. Ormsby 1,2, Timothy Penn 1,2, Santosh Poonnoose 2,4, Ganessan Kichenadasse 2,5 and Simon J. Conn 1,2,* 1 Flinders Cancer Research, … WebMechanistic studies revealed that circEIF4G3 bound to δ-catenin protein to promote its TRIM25-mediated ubiquitin degradation and interacted with miR-4449 to upregulate …
WebNov 16, 2024 · We show here that ME-circEIF4G3 is controlled by SRRM4 and, given the down-regulation of SRRM4 in gliomas and association with poor survival outcomes, this … WebCircEIF4G3 acts as a scaffold to promote δ-catenin ubiquitin degradation by TRIM25. (A) The expression of δ-catenin protein in GC cells with or without circEIF4G3 overexpression after treatment...
WebCircEIF4G3 destabilizes δ-catenin protein by enhancing TRIM25-mediated ubiquitin degradation and functions as a miRNA sponge to modulate miR-4449/SIK1 axis, which synergistically leads to the ...
WebCircEIF4G3 destabilizes δ-catenin protein and inactivates β-catenin signaling. (A) TRAP experiment and LC-MS/MS analysis. GST protein expression was detected by western blot. δ-catenin protein... css help discordWebResults Downregulated expression of circular RNA EIF4G3 (circEIF4G3; hsa_circ_0007991) was found in GC and was associated with poor clinical outcomes. Overexpression of circEIF4G3 suppressed GC growth and metastasis through the inhibition of β-catenin signaling, whereas knockdown of circEIF4G3 showed the opposite effects. css helplineWebBiogenesis Inc me circrna biogenesis factor Me Circrna Biogenesis Factor, supplied by Biogenesis Inc, used in various techniques. Bioz Stars score: 92/100, based on 3 PubMed citations. csshelp neoliberalWebNov 16, 2024 · Overexpressing SRRM4, known for regulating ME inclusion in mRNAs critical for neural differentiation, in human HEK293 cells resulted in the biogenesis of over 2000 novel ME-circRNAs, including ME-circEIF4G3, and changes in the abundance of many canonical circRNAs, including circSETDB2 and circLRBA. This shows SRRM4, in … css help forumWebAug 26, 2024 · CircEIF4G3 is expected to be a biomarker and therapeutic target for predicting the prognosis of gastric cancer. By analyzing the Master Gene Expression (GEO) dataset, we identified circRNAs that are differentially expressed in GCs. The researchers explored the biological role of circRNAs in GC through in vitro functional analysis and in … earl haig road hillington glasgowWebDec 13, 2024 · Gastric cancer (GC) is the third most common cause of cancer-related death worldwide. Advanced diagnosis and high rates of relapse and metastasis are associated with the poor prognosis of this disease. GC has a complex etiopathogenesis of which the underlying mechanisms remain to be explored. earl haig poppy fundWebAug 22, 2024 · This study found that CircEIF4G3 was down-regulated in gastric cancer patients and predicted poor prognosis. CircEIF4G3 destabilizes δ-catenin by forming a … css help login correctionssoftware.com