Buthionine sulfoximine bso
WebThe most widely used inhibitor has been buthionine sulfoximine (BSO), an analog of the glutamine synthetase (glutamate–ammonia ligase) inhibitor methionine sulfoximine. … WebAug 22, 2002 · Glutathione (GSH) is a ubiquitous intracellular tri-peptide that protects cells from oxidative stress and has been shown to detoxify alkylating agents. 9,10,11 Buthionine sulfoximine (BSO), a ...
Buthionine sulfoximine bso
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WebAug 20, 2024 · We pre-treated HeLa cells with buthionine sulfoximine (BSO) or a vehicle for 48 h to inhibit glutathione production and then expressed 3 × Flag-ATG14 or an empty vector for 24 h. Subsequently, cells were infected with CVB3 for 7 h and cell lysates were harvested for Western blot analysis ( Figure 5 C). WebJul 18, 2014 · sulfoximine (BSO) synergistically enhanced L-PAM activity (inducing 2–4 logs of cell kill) against nine MM cell lines (also in the presence of marrow stroma or cytokines) and in seven primary MM ...
WebLung cancer is the leading cause of cancer deaths in the United States with high incidence in tobacco smokers. Arylamine N-acetyltransferase 2 (NAT2) is a xenobiotic enzyme … Webprocess (Ambani et al., 1975). Because L-buthionine-[S,R]-sulfoximine (BSO) is an irreversible inhibitor of g-glutamylcysteine synthetase and causes glutathione depletion (Griffith and Meister, 1979), BSO toxicity can be used as a model of the disease (Andersen et al., 1996). In addition to these two neurotoxins, bleomycin sulfate
WebAug 31, 2024 · Herein, we report an l-buthionine-sulfoximine (BSO)-based hypertoxic self-assembled peptide derivative (NSBSO) with dual functions of GSH depletion and biosynthesis inhibition for selective tumor ferroptosis and pyroptosis. The NSBSO consists of a hydrophobic self-assembled peptide motif and a hydrophilic peptide derivative … WebButhionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis Breast Cancer Res. 2008;10(6 ... (GSH) and is resistant to estradiol-induced apoptosis. In the present study, we evaluated whether buthionine sulfoximine (BSO), a potent inhibitor of glutathione (GSH) synthesis, is capable of ...
WebReactive oxygen species (ROS), now appreciated for their cellular signaling capabilities, have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling, …
WebJul 31, 2015 · In this study, proteome and activities of glutathione (GSH)-related enzymes were investigated in detached leaves of Arabidopsis thaliana treated with ochratoxin A (OTA) alone or supplemented with buthionine sulfoximine (BSO, a specific inhibitor of the first step in GSH biosynthesis). A comparative proteomic study using two-dimensional … pitted skin makeupWebApr 16, 2024 · Blocking GSH production through use of l -buthionine sulfoximine (BSO), an inhibitor of the catalytic subunit of GCL (GCLC), has been proposed as a cancer therapy strategy. However, it is not ... bangladesh brasil argentinaWebCAS: 83730-53-4: Molecular Formula: C 8 H 18 N 2 O 3 S: Molecular Weight (g/mol) 222.31: MDL Number: MFCD00067000: InChI Key: KJQFBVYMGADDTQ-CVSPRKDYSA-N: Synonym: l-buthionine-sulfoximine, l-buthionine sulfoximine, 2s-2-amino-4-butylsulfonimidoyl butanoic acid, l-buthionine-s,r-sulfoximine, l-buthionine s,r … pitted queen olivesWebDec 30, 2024 · To deepen the mechanism of EVOOE antioxidant response in RT112 and J82 cells, we employed two modulators of GSH synthesis, the GSH precursor N-acetylcysteine (NAC) and the GSH inhibitor buthionine sulfoximine (BSO). pitted kalamataWebApr 13, 2024 · Osmotic minipumps were filled (control: Dulbecco’s phosphate-buffered saline (DPBS), no calcium, no magnesium; FAB: 1 µmol/L Aβ 42, 1 mmol/L FeSO 4, 12 mmol/L L-buthionine (S,R)-sulfoximine (BSO), and pH 5.1, brought to final volume with DPBS, no calcium, and no magnesium, as previously detailed) . Pumps were primed via … pittelWebMay 11, 2016 · Buthionine sulfoximine (BSO) is a sulfoximine which reduces levels of glutathione and is being investigated as an adjunct withchemotherapy in the treatment of cancer. The compound inhibits gamma-glutamylcysteine synthetase, the enzyme required in the first step of glutathione synthesis. bangladesh calendar 2020Webbiomolecules Review Role of HIF-1 in Alcohol-Mediated Multiple Organ Dysfunction Niya L. Morris 1,2 and Samantha M. Yeligar 1,2,* 1 Division of Pulmonary, Allergy, Critical Care … bangladesh calendar 2021